Communication

Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted-PEG-Based Micelles for the Treatment of Glioblastoma

  1. Erica Locatelli1,
  2. Francesca Broggi2,
  3. Jessica Ponti2,
  4. Patrick Marmorato2,
  5. Fabio Franchini2,
  6. Stefano Lena1,
  7. Mauro Comes Franchini1,*

Article first published online: 5 APR 2012

DOI: 10.1002/adhm.201100047

Issue

Advanced Healthcare Materials

Advanced Healthcare Materials

Volume 1, Issue 3, pages 342–347, May, 2012

Additional Information

How to Cite

Locatelli, E., Broggi, F., Ponti, J., Marmorato, P., Franchini, F., Lena, S. and Franchini, M. C. (2012), Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted-PEG-Based Micelles for the Treatment of Glioblastoma. Advanced Healthcare Materials, 1: 342–347. doi: 10.1002/adhm.201100047

Author Information

  1. 1

    Dipartimento di Chimica Organica, “A. Mangini”, University, Viale Risorgimento 4, 40136 Bologna, Italy, Fax: 390512093654

  2. 2

    European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Nanobiosciences Unit, Via E. Fermi 2749, 21027 Ispra, (VA), Italy.

*Dipartimento di Chimica Organica, “A. Mangini”, University, Viale Risorgimento 4, 40136 Bologna, Italy, Fax: 390512093654.

Publication History

  1. Issue published online: 4 MAY 2012
  2. Article first published online: 5 APR 2012
  3. Manuscript Revised: 13 MAR 2012
  4. Manuscript Received: 12 DEC 2011

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Keywords:

  • glioblastoma;
  • PEG-based polymer;
  • nanomedicine;
  • silver nanoparticles;
  • uptake
Thumbnail image of graphical abstract

A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell-specific recognition of the Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50 = 45 μM) has been found on glioblastoma cell lines.

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