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Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted-PEG-Based Micelles for the Treatment of Glioblastoma

Authors

  • Erica Locatelli,

    1. Dipartimento di Chimica Organica, “A. Mangini”, University, Viale Risorgimento 4, 40136 Bologna, Italy, Fax: 390512093654
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  • Francesca Broggi,

    1. European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Nanobiosciences Unit, Via E. Fermi 2749, 21027 Ispra, (VA), Italy.
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  • Jessica Ponti,

    1. European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Nanobiosciences Unit, Via E. Fermi 2749, 21027 Ispra, (VA), Italy.
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  • Patrick Marmorato,

    1. European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Nanobiosciences Unit, Via E. Fermi 2749, 21027 Ispra, (VA), Italy.
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  • Fabio Franchini,

    1. European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Nanobiosciences Unit, Via E. Fermi 2749, 21027 Ispra, (VA), Italy.
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  • Stefano Lena,

    1. Dipartimento di Chimica Organica, “A. Mangini”, University, Viale Risorgimento 4, 40136 Bologna, Italy, Fax: 390512093654
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  • Mauro Comes Franchini

    Corresponding author
    1. Dipartimento di Chimica Organica, “A. Mangini”, University, Viale Risorgimento 4, 40136 Bologna, Italy, Fax: 390512093654
    • Dipartimento di Chimica Organica, “A. Mangini”, University, Viale Risorgimento 4, 40136 Bologna, Italy, Fax: 390512093654.
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Abstract

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A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell-specific recognition of the Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50 = 45 μM) has been found on glioblastoma cell lines.

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