Communication

Fabrication of a Hybrid Microfluidic System Incorporating both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network

  1. Leon M. Bellan1,*,
  2. Tatiana Kniazeva3,
  3. Ernest S. Kim3,
  4. Alla A. Epshteyn3,
  5. Donald M. Cropek2,
  6. Robert Langer1,
  7. Jeffrey T. Borenstein3

Article first published online: 20 JAN 2012

DOI: 10.1002/adhm.201100052

Issue

Advanced Healthcare Materials

Advanced Healthcare Materials

Volume 1, Issue 2, pages 164–167, March, 2012

Additional Information

How to Cite

Bellan, L. M., Kniazeva, T., Kim, E. S., Epshteyn, A. A., Cropek, D. M., Langer, R. and Borenstein, J. T. (2012), Fabrication of a Hybrid Microfluidic System Incorporating both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network. Advanced Healthcare Materials, 1: 164–167. doi: 10.1002/adhm.201100052

Author Information

  1. 1

    Massachusetts Institute of Technology, 77 Massachusetts Avenue, The David H. Koch Institute, Room 76-661, Cambridge, MA 02139-4307

  2. 2

    U.S. Army Corps of Engineers, Construction Engineering Research Laboratory, Champaign, IL 61822

  3. 3

    Draper Laboratory, Biomedical Engineering Center, Mail Stop 32, 555 Technology Square, Cambridge, MA 02139

*Massachusetts Institute of Technology, 77 Massachusetts Avenue, The David H. Koch Institute, Room 76-661, Cambridge, MA 02139-4307.

Publication History

  1. Issue published online: 16 MAR 2012
  2. Article first published online: 20 JAN 2012
  3. Manuscript Revised: 29 DEC 2011
  4. Manuscript Received: 11 OCT 2011

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Keywords:

  • microfluidics;
  • vascular;
  • 3D;
  • resistance;
  • microfiber
Thumbnail image of graphical abstract

A device containing a 3D microchannel network (fabricated using sacrificial melt-spun microfibers) sandwiched between lithographically patterned microfluidic channels offers improved delivery of soluble compounds to a large volume compared to a simple stack of two microfluidic channel layers. With this improved delivery ability comes an increased fluidic resistance due to the tortuous network of small-diameter channels.

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