Dual-Imaging Enabled Cancer-Targeting Nanoparticles

Authors

  • Aniket S. Wadajkar,

    1. Department of Bioengineering, The University of Texas at Arlington, 500 UTA Boulevard, Arlington 76019, TX, USA
    2. Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas, Southwestern Medical Center, Dallas 75390, TX, USA
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  • Tejaswi Kadapure,

    1. Department of Bioengineering, The University of Texas at Arlington, 500 UTA Boulevard, Arlington 76019, TX, USA
    2. Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas, Southwestern Medical Center, Dallas 75390, TX, USA
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  • Yi Zhang,

    1. Department of Bioengineering, The University of Texas at Arlington, 500 UTA Boulevard, Arlington 76019, TX, USA
    2. Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas, Southwestern Medical Center, Dallas 75390, TX, USA
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  • Weina Cui,

    1. Department of Radiology, The University of Texas Southwestern Medical Center, Dallas 75390, TX, USA
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  • Kytai T. Nguyen,

    Corresponding author
    1. Department of Bioengineering, The University of Texas at Arlington, 500 UTA Boulevard, Arlington 76019, TX, USA
    2. Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas, Southwestern Medical Center, Dallas 75390, TX, USA
    • Department of Bioengineering, The University of Texas at Arlington, 500 UTA Boulevard, Arlington 76019, TX, USA.
    Search for more papers by this author
  • Jian Yang

    Corresponding author
    1. Department of Bioengineering, The University of Texas at Arlington, 500 UTA Boulevard, Arlington 76019, TX, USA
    2. Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas, Southwestern Medical Center, Dallas 75390, TX, USA
    • Department of Bioengineering, The University of Texas at Arlington, 500 UTA Boulevard, Arlington 76019, TX, USA.
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Abstract

original image

The development of dual-imaging enabled cancer-targeting nanoparticles (DICT-NPs) is reported based on newly developed biodegradable photoluminescent polymers and superparamagnetic iron oxide nanoparticles. DICT-NPs possess capabilities of dual-imaging (magnetic resonance imaging and optical imaging), magnetic targeting, and potentially selective targeting for cancer cells. The development of DICT-NPs addresses the concerns in dual-imaging nanoparticles where photobleaching organic dyes and cytotoxic quantum dots are usually adopted.

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