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Keywords:

  • biodegradable photoluminescent polymers;
  • biomaterial-mediated cellular uptake;
  • magnetic resonance imaging;
  • optical imaging;
  • superparamagnetic nanoparticles
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The development of dual-imaging enabled cancer-targeting nanoparticles (DICT-NPs) is reported based on newly developed biodegradable photoluminescent polymers and superparamagnetic iron oxide nanoparticles. DICT-NPs possess capabilities of dual-imaging (magnetic resonance imaging and optical imaging), magnetic targeting, and potentially selective targeting for cancer cells. The development of DICT-NPs addresses the concerns in dual-imaging nanoparticles where photobleaching organic dyes and cytotoxic quantum dots are usually adopted.