Synthesis of Tunable Theranostic Fe3O4@Mesoporous Silica Nanospheres for Biomedical Applications

Authors

  • Yang Zhao,

    1. Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale Department of Chemistry, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China, Fax: +86 551 3603040
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  • Li-Ning Lin,

    1. Department of Materials of Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China
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  • Yang Lu,

    1. Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale Department of Chemistry, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China, Fax: +86 551 3603040
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  • Huai-Ling Gao,

    1. Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale Department of Chemistry, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China, Fax: +86 551 3603040
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  • Shao-Feng Chen,

    1. Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale Department of Chemistry, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China, Fax: +86 551 3603040
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  • Ping Yang,

    1. Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale Department of Chemistry, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China, Fax: +86 551 3603040
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  • Shu-Hong Yu

    Corresponding author
    1. Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale Department of Chemistry, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China, Fax: +86 551 3603040
    • Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences, at Microscale Department of Chemistry, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China, Fax: +86 551 3603040.
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Abstract

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Tunable theranostic Fe3O4@mesoporous silica nanospheres: Tunable theranostic Fe3O4@mesoporous silica nanospheres for diagnosis and gene therapy have been designed. The tunable delivery doses of imaging probe and gene by Fe3O4@mesoporous silica nanospheres can be realized by the tunable magnetic cores and modification of surface charges. These Fe3O4@mesoporous silica nanospheres may act as a theranostic nanosystem due to good biocompatibility, effective MRI diagnosis and gene delivery capabilities.

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