Communication

Efficient Cell Reprogramming Using Bioengineered Surfaces

  1. David Horna2,
  2. Juan Carlos Ramírez1,
  3. Anna Cifuentes2,
  4. Antonio Bernad1,
  5. Salvador Borrós2,
  6. Manuel A. González1,*

Article first published online: 16 FEB 2012

DOI: 10.1002/adhm.201200017

Issue

Advanced Healthcare Materials

Advanced Healthcare Materials

Volume 1, Issue 2, pages 177–182, March, 2012

Additional Information

How to Cite

Horna, D., Ramírez, J. C., Cifuentes, A., Bernad, A., Borrós, S. and González, M. A. (2012), Efficient Cell Reprogramming Using Bioengineered Surfaces. Advanced Healthcare Materials, 1: 177–182. doi: 10.1002/adhm.201200017

Author Information

  1. 1

    Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain

  2. 2

    Grup d'Enginyeria de Materials (GEMAT), Institut Químic de Sarrià-Universitat Ramon Llull, Via Augusta 390, 08017 Barcelona, Spain

*Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain.

Publication History

  1. Issue published online: 16 MAR 2012
  2. Article first published online: 16 FEB 2012
  3. Manuscript Received: 20 JAN 2012

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (3502K)

Keywords:

  • surface modification;
  • bioactive surfaces;
  • cell reprogramming
Thumbnail image of graphical abstract

A novel method for cell reprogramming is been developed by immobilizing nucleic acid transfer vectors containing free amino groups, like lentiviral particles, onto pentafluorophenyl methacrylate (PFM)-modified surfaces obtained by PFM grafting affter Ar plasma treatment. This technique is able to reprogram murine somatic cells into pluripotent cells at high efficiencies. We call these modified surfaces cell reprogramming surfaces, or CRS.

View Full Article with Supporting Information (HTML) Get PDF (3502K)