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Keywords:

  • barium;
  • biomedical application;
  • nanostructure;
  • X-ray computed tomography;
  • ytterbium
Thumbnail image of graphical abstract

A novel CT contrast agent denoted as BaYbF5@SiO2@PEG is presented. The as-prepared nanoparticles exhibit significantly enhanced contrast efficacy relative to clinical iodinated agents and maintain higher X-ray attenuation at different voltages, suitable for diagnostic imaging of various patients. Prolonged circulation time in vivo and low toxicity mean the nanoparticles perform excellently in in-vivo X-ray CT angiography.