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Hybrid BaYbF5 Nanoparticles: Novel Binary Contrast Agent for High-Resolution in Vivo X-ray Computed Tomography Angiography

Authors

  • Yanlan Liu,

    1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, P. R. China
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  • Kelong Ai,

    1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
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  • Jianhua Liu,

    1. Department of Radiology, the Second Hospital of Jilin University Norman Bethune, Changchun 130022, P. R. China
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  • Qinghai Yuan,

    1. Department of Radiology, the Second Hospital of Jilin University Norman Bethune, Changchun 130022, P. R. China
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  • Yangyang He,

    1. Department of Pathology, the Second Hospital of Jilin University Norman Bethune, Changchun 130022, P. R. China
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  • Lehui Lu

    Corresponding author
    1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
    • State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
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Abstract

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A novel CT contrast agent denoted as BaYbF5@SiO2@PEG is presented. The as-prepared nanoparticles exhibit significantly enhanced contrast efficacy relative to clinical iodinated agents and maintain higher X-ray attenuation at different voltages, suitable for diagnostic imaging of various patients. Prolonged circulation time in vivo and low toxicity mean the nanoparticles perform excellently in in-vivo X-ray CT angiography.

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