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Biomineralization-Based Virus Shell-Engineering: Towards Neutralization Escape and Tropism Expansion

Authors

  • Xiaoyu Wang,

    Corresponding author
    1. Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027 (China)
    2. Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, Zhejiang, 310027, China
    • Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027 (China)
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  • Yongqiang Deng,

    1. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
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  • Shihua Li,

    1. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
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  • Guangchuan Wang,

    1. Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027 (China)
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  • Ede Qin,

    1. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
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  • Xurong Xu,

    1. Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027 (China)
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  • Ruikang Tang,

    Corresponding author
    1. Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027 (China)
    • Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027 (China)
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  • Chengfeng Qin

    Corresponding author
    1. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
    • State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China.
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Abstract

original image

Biomineralization-based virus shell-engineering (BVSE) is a potential surface modification strategy to afford a biocompatible and biodegradable calcium phosphate (CaPi) shell onto single virus, allowing development of Trojan virus with enhanced infection, expanded tropism and neutralization escape, which open up the multiple applications of virus in biomedicines and materials.

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