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Keywords:

  • cartilage;
  • controlled release;
  • hydrogels;
  • latent TGF-β;
  • tissue engineering
Thumbnail image of graphical abstract

A biomimetic delivery strategy for transforming growth factor beta (TGF-β) is described, in which TGF-β is presented in a latent form (the small latent complex, SLC), which is inactive until modified by the actions of the cells. In this work, SLC is tethered to a hyaluronic acid hydrogel scaffold to enhance in vitro chondrogenesis.