Stealth Rare Earth Oxide Nanodiscs for Magnetic Resonance Imaging



original image

Configuring RE2O3 nanocrystals with pseudo-2D morphologies confers substantive gains in relaxivities over equivalent spherical counterparts. The most promising arises from Gd2O3 whose ionic transverse and longitudinal relaxivities were as high as r1 = 12.7 mM−1 s−1 and r2 = 17.2 mM−1 s−1 (dispersed in H2O, T = 37 °C & B0 = 1.41 T), pointing to new opportunities to achieve high contrast MRI while concomitantly affording longer half-life potential in vivo.