Hierarchical Porous Carbide-Derived Carbons for the Removal of Cytokines from Blood Plasma

Authors

  • Volker Presser,

    1. Department of Materials Science and Engineering, A. J. Drexel Nanotechnology Institute, Drexel University, 3141 Chestnut Street, Philadelphia, PA, 19104, USA
    2. Energy Materials Group, INM - Leibniz-Institut für Neue Materialien gGmbH, Campus D2 2, D-66123 Saarbrücken, Germany
    Search for more papers by this author
  • Sun-Hwa Yeon,

    1. Distributed Power Generation and Energy Storage Group, Korea Institute of Energy Research, Daejeon, 305-343, South Korea
    Search for more papers by this author
  • Cekdar Vakifahmetoglu,

    1. Department of Mechanical Engineering, Istanbul Kemerburgaz University, Mahmutbey Dilmenler Caddesi, No:26, 34217 Bagcilar, Istanbul, Turkey
    Search for more papers by this author
  • Carol A. Howell,

    1. School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton BN2 4GJ, UK
    Search for more papers by this author
  • Susan R. Sandeman,

    1. School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton BN2 4GJ, UK
    Search for more papers by this author
  • Paolo Colombo,

    1. Dipartimento di Ingegneria Meccanica–Settore Materiali, University of Padova, 35131 Padova, Italy & Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA 16802, USA
    Search for more papers by this author
  • Sergey Mikhalovsky,

    Corresponding author
    1. School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton BN2 4GJ, UK
    2. School of Engineering, Nazarbayev University, 53 Kabanbay batyr ave., Astana, 010000, Kazakhstan
    • School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton BN2 4GJ, UK.
    Search for more papers by this author
  • Yury Gogotsi

    Corresponding author
    1. Department of Materials Science and Engineering, A. J. Drexel Nanotechnology Institute, Drexel University, 3141 Chestnut Street, Philadelphia, PA, 19104, USA
    • Department of Materials Science and Engineering, A. J. Drexel Nanotechnology Institute, Drexel University, 3141 Chestnut Street, Philadelphia, PA, 19104, USA
    Search for more papers by this author

Abstract

original image

A series of silicon carbonitride ceramics is utilized to obtain hierarchically porous carbide-derived carbons (CDCs) for cytokine removal. The removal rate of TNF-α and IL-6, as two examples of pro- and anti-inflammatory cytokines, is proportional to the surface area of pores larger than the size of the protein molecule.

Ancillary