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Keywords:

  • lanthanide nanostructure;
  • photocatalysis;
  • near infrared activation;
  • drug delivery;
  • targeted cancer cell ablation
Thumbnail image of graphical abstract

Nanomedicine: NIR-active N-TiO2/NaYF4:Yb,Tm nanocomposites (NCs) were synthesized for the first time and its potential applications in drug release and targeted cancer cell ablation are explored. Upon 980 nm laser irradiation, the anti-cAngptl4 Ab-conjugated N-TiO2/NaYF4:Yb,Tm NCs shows a significant increase in apoptotic A-5RT3 cells when compared with that of the unconjugated NCs. The mechanisms for NIR-induced photocatalysis, drug release and targeted cancer cell killing are proposed.