Anti-cAngptl4 Ab-Conjugated N-TiO2/NaYF4:Yb,Tm Nanocomposite for Near Infrared-Triggered Drug Release and Enhanced Targeted Cancer Cell Ablation

Authors

  • Qing Chi Xu,

    1. School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459 Singapore
    Current affiliation:
    1. These authors contributed equally to this work
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  • Yan Zhang,

    1. School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459 Singapore
    Current affiliation:
    1. These authors contributed equally to this work
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  • Ming Jie Tan,

    1. School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551 Singapore
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  • Yang Liu,

    1. School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459 Singapore
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  • Shaojun Yuan,

    1. School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798 Singapore
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  • Cleo Choong,

    1. School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798 Singapore
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  • Nguan Soon Tan,

    1. School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551 Singapore, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Building, 138673 Singapore
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  • Timothy Thatt Yang Tan

    Corresponding author
    1. School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459 Singapore
    • School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459 Singapore.
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Abstract

original image

Nanomedicine: NIR-active N-TiO2/NaYF4:Yb,Tm nanocomposites (NCs) were synthesized for the first time and its potential applications in drug release and targeted cancer cell ablation are explored. Upon 980 nm laser irradiation, the anti-cAngptl4 Ab-conjugated N-TiO2/NaYF4:Yb,Tm NCs shows a significant increase in apoptotic A-5RT3 cells when compared with that of the unconjugated NCs. The mechanisms for NIR-induced photocatalysis, drug release and targeted cancer cell killing are proposed.

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