Direct-Write Assembly of 3D Silk/Hydroxyapatite Scaffolds for Bone Co-Cultures

Authors

  • Lin Sun,

    1. Department of Chemical and Biological Engineering and Biomedical Engineering, Tufts University, Medford, MA 02155, USA
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  • Sara T. Parker,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
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  • Daisuke Syoji,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
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  • Xiuli Wang,

    1. Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA
    2. Dalian Institute of Chemical and Physics, Chinese Academy of Sciences, 116023, China
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  • Jennifer A. Lewis,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
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  • David L. Kaplan

    Corresponding author
    1. Department of Chemical and Biological Engineering and Biomedical Engineering, Tufts University, Medford, MA 02155, USA
    2. Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA
    • Department of Chemical and Biological Engineering and Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
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Abstract

original image

3D silk/HA microperiodic scaffolds for bone tissue engineering and angiogenesis are fabricated by direct-write assembly. This approach can be used to control filament and spacing size in the scaffold to allow investigation of the effect of scaffold architecture on osteogenesis and vessel-like structure formation from stem cells and endothelial cells.

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