The Next Step in Biomimetic Material Design: Poly-LacNAc-Mediated Reversible Exposure of Extra Cellular Matrix Components

Authors

  • Meike V. Beer,

    1. Department of Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, 97070 Würzburg, Germany
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Claudia Rech,

    1. Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstr. 20, 52074 Aachen, Germany
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Peter Gasteier,

    1. Interactive Materials Research Institute (DWI e.V.) and Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Forckenbeckstr. 50, 52074 Aachen, Germany
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  • Birgit Sauerzapfe,

    1. Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstr. 20, 52074 Aachen, Germany
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  • Jochen Salber,

    1. Interactive Materials Research Institute (DWI e.V.) and Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Forckenbeckstr. 50, 52074 Aachen, Germany
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  • Andrea Ewald,

    1. Department of Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, 97070 Würzburg, Germany
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  • Martin Möller,

    1. Interactive Materials Research Institute (DWI e.V.) and Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Forckenbeckstr. 50, 52074 Aachen, Germany
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  • Lothar Elling,

    Corresponding author
    1. Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstr. 20, 52074 Aachen, Germany
    • Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstr. 20, 52074 Aachen, Germany.
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  • Jürgen Groll

    Corresponding author
    1. Department of Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, 97070 Würzburg, Germany
    • Department of Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, 97070 Würzburg, Germany
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Abstract

original image

Herein is demonstrated that a biomimetic, in-vivo-like presentation of extracellular matrix (ECM) proteins such as fibronectin, laminin, and collagen IV mediated by a fully functional poly-sugar (polyLacNAc)–lectin complex can be achieved on a biomaterials surface. Cells recognize and bind to these immobilized proteins and can, due to the reversible protein presentation, remodel initially presented ECM proteins.

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