This article is dedicated to the memory of Shri Makhan Chandra Borah (b. October 5, 1931, d. January 24, 2012, Borbheta, Jorhat, Assam), teacher, Gandhian, silk rearer and social worker who provided valuable advice for our sericulture experiments.
Silk Fibroin in Tissue Engineering†
Article first published online: 4 JUN 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Advanced Healthcare Materials
Volume 1, Issue 4, pages 393–412, July, 2012
How to Cite
Kasoju, N. and Bora, U. (2012), Silk Fibroin in Tissue Engineering. Advanced Healthcare Materials, 1: 393–412. doi: 10.1002/adhm.201200097
- Issue published online: 6 JUL 2012
- Article first published online: 4 JUN 2012
- Manuscript Received: 29 MAR 2012
- biocompatible materials;
- biodegradable materials;
- silk fibroin;
- tissue engineering;
Tissue engineering (TE) is a multidisciplinary field that aims at the in vitro engineering of tissues and organs by integrating science and technology of cells, materials and biochemical factors. Mimicking the natural extracellular matrix is one of the critical and challenging technological barriers, for which scaffold engineering has become a prime focus of research within the field of TE. Amongst the variety of materials tested, silk fibroin (SF) is increasingly being recognized as a promising material for scaffold fabrication. Ease of processing, excellent biocompatibility, remarkable mechanical properties and tailorable degradability of SF has been explored for fabrication of various articles such as films, porous matrices, hydrogels, nonwoven mats, etc., and has been investigated for use in various TE applications, including bone, tendon, ligament, cartilage, skin, liver, trachea, nerve, cornea, eardrum, dental, bladder, etc. The current review extensively covers the progress made in the SF-based in vitro engineering and regeneration of various human tissues and identifies opportunities for further development of this field.