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Electrical Stimulation of Myoblast Proliferation and Differentiation on Aligned Nanostructured Conductive Polymer Platforms

Authors

  • Anita F. Quigley,

    1. ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, Innovation Campus, Squires Way, North Wollongong NSW 2522, Australia
    2. Centre for Clinical Neuroscience and Neurology, Research and Department of Medicine, The University of Melbourne, St. Vincent's Hospital, 41 Victoria Pde, Fitzroy, VIC 3065, Australia
    Current affiliation:
    1. A. F. Q. and J. M. R. contributed equally to this work.
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  • Joselito M. Razal,

    1. ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, Innovation Campus, Squires Way, North Wollongong NSW 2522, Australia
    Current affiliation:
    1. A. F. Q. and J. M. R. contributed equally to this work.
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  • Magdalena Kita,

    1. ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, Innovation Campus, Squires Way, North Wollongong NSW 2522, Australia
    2. Centre for Clinical Neuroscience and Neurology, Research and Department of Medicine, The University of Melbourne, St. Vincent's Hospital, 41 Victoria Pde, Fitzroy, VIC 3065, Australia
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  • Rohoullah Jalili,

    1. ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, Innovation Campus, Squires Way, North Wollongong NSW 2522, Australia
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  • Amy Gelmi,

    1. ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, Innovation Campus, Squires Way, North Wollongong NSW 2522, Australia
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  • Anthony Penington,

    1. Centre for Clinical Neuroscience and Neurology, Research and Department of Medicine, The University of Melbourne, St. Vincent's Hospital, 41 Victoria Pde, Fitzroy, VIC 3065, Australia
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  • Raquel Ovalle-Robles,

    1. Alan G. MacDiarmid NanoTech Institute, University of Texas at Dallas, Richardson, Texas 75080, USA
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  • Ray H. Baughman,

    1. Alan G. MacDiarmid NanoTech Institute, University of Texas at Dallas, Richardson, Texas 75080, USA
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  • Graeme M. Clark,

    1. ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, Innovation Campus, Squires Way, North Wollongong NSW 2522, Australia
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  • Gordon G. Wallace,

    Corresponding author
    1. ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, Innovation Campus, Squires Way, North Wollongong NSW 2522, Australia
    • ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, Innovation Campus, Squires Way, North Wollongong NSW 2522, Australia.
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  • Robert M. I. Kapsa

    Corresponding author
    1. ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, Innovation Campus, Squires Way, North Wollongong NSW 2522, Australia
    2. Centre for Clinical Neuroscience and Neurology, Research and Department of Medicine, The University of Melbourne, St. Vincent's Hospital, 41 Victoria Pde, Fitzroy, VIC 3065, Australia
    • ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, Innovation Campus, Squires Way, North Wollongong NSW 2522, Australia.
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Abstract

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In this study, nanostructured conductive platforms synthesized from aligned multiwalled carbon nanotubes and polypyrrole are investigated as myo-regenerative scaffolds. Myotube formation follows a linear path on the platforms coinciding with extent of nanotopography. In addition, electrical stimulation enhances myo-nuclear number and differentiation. These studies demonstrate that conductive polymer platforms can be used to influence muscle cell behaviour through nanostructure and electrical stimulation.

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