Efficient, pH-Triggered Drug Delivery Using a pH-Responsive DNA-Conjugated Gold Nanoparticle



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A novel drug nanocarrier that offers simple, direct, native form drug loading without involving any chemical modification and/or coupling step has been developed by using a pH-responsive DNA–gold nanoparticle conjugate. It can resist non-specific adsorption of serum proteins upon PEGylation and can provide efficient delivery and pH-triggered release of anticancer drugs to cancer cells, leading to high cytotoxicity.