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Metabolomics Studies Show Dose-Dependent Toxicity Induced by SiO2 Nanoparticles in MRC-5 Human Fetal Lung Fibroblasts

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Metabolomics measures a comprehensive range of metabolites and is applied here to understand cellular toxicity of nano-SiO2. Silica nanoparticles are assessed for their effects on MRC-5 lung fibroblasts and initial investigations reveal no significant alterations in cell viability and morphology. Further metabolomic analysis reveals dose-dependent alterations in cellular metabolism due to nano-SiO2 exposure. This methodology may be a potentially useful analytical platform to investigate nanotoxicity.

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