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A Hybrid Hydrogel Biomaterial by Nanogel Engineering: Bottom-Up Design with Nanogel and Liposome Building Blocks to Develop a Multidrug Delivery System

  1. Yurina Sekine1,2,
  2. Yuki Moritani3,
  3. Tomoko Ikeda-Fukazawa4,
  4. Yoshihiro Sasaki1,5,
  5. Kazunari Akiyoshi1,2,6,7,*

Article first published online: 29 AUG 2012

DOI: 10.1002/adhm.201200175

Issue

Advanced Healthcare Materials

Advanced Healthcare Materials

Volume 1, Issue 6, pages 722–728, November, 2012

Additional Information

How to Cite

Sekine, Y., Moritani, Y., Ikeda-Fukazawa, T., Sasaki, Y. and Akiyoshi, K. (2012), A Hybrid Hydrogel Biomaterial by Nanogel Engineering: Bottom-Up Design with Nanogel and Liposome Building Blocks to Develop a Multidrug Delivery System. Advanced Healthcare Materials, 1: 722–728. doi: 10.1002/adhm.201200175

Author Information

  1. 1

    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan

  2. 2

    Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University, Tokyo, Japan

  3. 3

    Research Laboratories, NTT Docomo Inc., Kanagawa, Japan

  4. 4

    Department of Applied Chemistry, Meiji University, Kanagawa, Japan

  5. 5

    PRESTO, Japan Science and Technology Agency, Tokyo, Japan

  6. 6

    Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan

  7. 7

    ERATO, Japan Science and Technology Agency (JST), Chiyoda-ku, Tokyo 102-0076, Japan

*Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.

Publication History

  1. Issue published online: 2 NOV 2012
  2. Article first published online: 29 AUG 2012
  3. Manuscript Revised: 30 JUN 2012
  4. Manuscript Received: 22 MAY 2012

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Keywords:

  • hybrid hydrogels;
  • nanogels;
  • polysaccharides;
  • liposomes;
  • superparamagnetic iron oxide nanoparticles

Abstract

New hybrid poly(ethylene glycol) (PEG) hydrogels crosslinked with both nanogels and nanogel-coated liposome complexes are obtained by Michael addition of the acryloyl group of a cholesterol-bearing pullulan (CHP) nanogel to the thiol group of pentaerythritol tetra(mercaptoethyl) polyoxyethylene. The nanogel-coated liposome complex is stably retained after gelation and the complexes are well dispersed in the hybrid gel. Microrheological measurements show that the strength and gelation time of the hybrid hydrogel can be controlled by changing the liposome:nanogel ratio. The hydrogel is gradually degraded by hydrolysis under physiological conditions. In this process, the nanogel is released first, followed by the nanogel-coated liposomes. Hybrid hydrogels that can incorporate various molecules into the nanogel and liposomes, and release them in a two-step controllable manner, represent a new functional scaffold capable of delivering multiple drugs, proteins or DNA.

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