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Multifunctional Hybrid Nanocarriers Consisting of Supramolecular Polymers and Quantum Dots for Simultaneous Dual Therapeutics Delivery and Cellular Imaging

Authors

  • Yun-Long Wu,

    1. Department of Bioengineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, Singapore 117574, Singapore
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  • Hui Yin,

    1. Department of Bioengineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, Singapore 117574, Singapore
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  • Feng Zhao,

    1. Department of Bioengineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, Singapore 117574, Singapore
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  • Jun Li

    Corresponding author
    1. Department of Bioengineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, Singapore 117574, Singapore
    2. Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 3 Research Link, Singapore 117602, Singapore
    • Department of Bioengineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, Singapore 117574, Singapore.
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Abstract

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A novel multifunctional hybrid nanocarrier consisting of a red fluorescence quantum dot core and a star-shaped cationic β-cyclodextrin polymer shell is demonstrated. Chemotherapeutic drug paclitaxel is supramolecularly preloaded into the nanocarrier, which co-delivers the drug and DNA with an enhanced gene expression, while the quantum dot core allows simultaneous cellular imaging using laser scanning confocal microscopy.

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