Get access

Construction of 3D, Layered Skin, Microsized Tissues by Using Cell Beads for Cellular Function Analysis

Authors

  • Yuya Morimoto,

    1. Center for International Research on, Micronano Mechatronics (CIRMM), Institute of Industrial Science (IIS), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan
    Current affiliation:
    1. These authors have contributed equally to this work.
    Search for more papers by this author
  • Risa Tanaka,

    1. Center for International Research on, Micronano Mechatronics (CIRMM), Institute of Industrial Science (IIS), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan
    Current affiliation:
    1. These authors have contributed equally to this work.
    Search for more papers by this author
  • Shoji Takeuchi

    Corresponding author
    1. Center for International Research on, Micronano Mechatronics (CIRMM), Institute of Industrial Science (IIS), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan
    2. ERATO, Japan Science and Technology (JST), Komaba Open Laboratory (KOL) Room M202, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan
    • Center for International Research on, Micronano Mechatronics (CIRMM), Institute of Industrial Science (IIS), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.
    Search for more papers by this author

Abstract

original image

Microsized skin cell beads consisting of 3D layered structures with epidermal and dermal cells have been fabricated. The beads are monodisperse, type-I collagen beads encapsulating dermal cells and covered by epidermal cells. The beads can be used in individual analyses of cellular functions and respond to chemical stimulation.

Get access to the full text of this article

Ancillary