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Top-Down Fabrication of Polyelectrolyte-Thermoplastic Hybrid Microparticles for Unidirectional Drug Delivery to Single Cells

Authors

  • Peipei Zhang,

    1. Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Integrative NanoScience Institute, Florida State University, Tallahassee, FL 32310, USA
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  • Yingru Liu,

    1. Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Integrative NanoScience Institute, Florida State University, Tallahassee, FL 32310, USA
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  • Junfei Xia,

    1. Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Integrative NanoScience Institute, Florida State University, Tallahassee, FL 32310, USA
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  • Zhibin Wang,

    1. Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Integrative NanoScience Institute, Florida State University, Tallahassee, FL 32310, USA
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  • Brett Kirkland,

    1. Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Integrative NanoScience Institute, Florida State University, Tallahassee, FL 32310, USA
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  • Jingjiao Guan

    Corresponding author
    1. Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Integrative NanoScience Institute, Florida State University, Tallahassee, FL 32310, USA
    • Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Integrative NanoScience Institute, Florida State University, Tallahassee, FL 32310, USA.
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Abstract

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This manuscript describes an inexpensive and versatile top-down method to produce microparticles that integrate both thermoplastics and polyelectrolytes with a unique dot-on-pad structure. These particles may allow in vivo unidirectional drug delivery to single cells.

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