Hierarchical Fibrillar Scaffolds Obtained by Non-conventional Layer-By-Layer Electrostatic Self-Assembly

Authors

  • Sara M. Oliveira,

    1. 3Bs Research Group–Biomaterials, Biodegradables and Biomimetics, AvePark, Zona Industrial da Gandra S. Claúdio do Barco, 4806-909 Caldas das Taipas - Guimarães, Portugal
    2. ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal
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  • Tiago H. Silva,

    Corresponding author
    1. 3Bs Research Group–Biomaterials, Biodegradables and Biomimetics, AvePark, Zona Industrial da Gandra S. Claúdio do Barco, 4806-909 Caldas das Taipas - Guimarães, Portugal
    2. ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal
    • 3Bs Research Group–Biomaterials, Biodegradables and Biomimetics, AvePark, Zona Industrial da Gandra S. Claúdio do Barco, 4806-909 Caldas das Taipas - Guimarães, Portugal.
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  • Rui L. Reis,

    1. 3Bs Research Group–Biomaterials, Biodegradables and Biomimetics, AvePark, Zona Industrial da Gandra S. Claúdio do Barco, 4806-909 Caldas das Taipas - Guimarães, Portugal
    2. ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal
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  • João F. Mano

    1. 3Bs Research Group–Biomaterials, Biodegradables and Biomimetics, AvePark, Zona Industrial da Gandra S. Claúdio do Barco, 4806-909 Caldas das Taipas - Guimarães, Portugal
    2. ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal
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Abstract

original image

A new application of layer-by-layer assembly is presented, able to create nano/micro fibrils or nanocoatings inside 3D scaffolds using non-fibrillar polyelectrolytes for tissue-engineering applications. This approach shows promise for developing advanced scaffolds with controlled nano/micro environments, and nature and architectures similar to the natural extracellular matrix, leading to improved biological performance.

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