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Keywords:

  • biological mimicking;
  • cell biotinylation;
  • gene delivery;
  • hindlimb ischemia;
  • ligand–receptor principle
Thumbnail image of graphical abstract

A facile and flexible targeting gene-delivery strategy is reported by mimicking the biological ligand–receptor principle based on avidin–biotin interaction. In vitro and in vivo investigations demonstrate that this strategy provides a simple, but universal alternative for potential target gene delivery as well as drug delivery.