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Keywords:

  • negative photoresists;
  • polydimethylsiloxane;
  • pluripotent stem cells;
  • cellular phenotypes;
  • gene expression
Thumbnail image of graphical abstract

Microfabrication materials such as polydimethylsiloxane (PDMS) and photoresists (PRs) permit the creation of nano/microstructured substrates that enable the direct control of the cellular functions and phenotypes of human pluripotent stem cells (hPSCs). The multiple analyses of cellular phenotypes and gene expression demonstrate that microfabrication materials preferentially direct hPSCs towards differentiation.