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Ultrasmall Manganese Ferrite Nanoparticles as Positive Contrast Agent for Magnetic Resonance Imaging

Authors

  • Zhen Li,

    Corresponding author
    1. Institute of Superconducting & Electronic Materials, The University of Wollongong, NSW 2500, Australia
    Current affiliation:
    1. Z.L. and S.X.W. made equal contributions to this work.
    • Institute of Superconducting & Electronic Materials, The University of Wollongong, NSW 2500, Australia
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  • Shu Xia Wang,

    1. Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics & Mathematics, Chinese Academy of Sciences, Wuhan 430071, P. R. China
    Current affiliation:
    1. Z.L. and S.X.W. made equal contributions to this work.
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  • Qiao Sun,

    1. ARC Centre of Excellence for Functional Nanomaterials, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, QLD 4072, Australia
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  • Hong Li Zhao,

    1. Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, P. R. China
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  • Hao Lei,

    1. Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics & Mathematics, Chinese Academy of Sciences, Wuhan 430071, P. R. China
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  • Min Bo Lan,

    1. Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, P. R. China
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  • Zhen Xiang Cheng,

    1. Institute of Superconducting & Electronic Materials, The University of Wollongong, NSW 2500, Australia
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  • Xiao Lin Wang,

    1. Institute of Superconducting & Electronic Materials, The University of Wollongong, NSW 2500, Australia
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  • Shi Xue Dou,

    1. Institute of Superconducting & Electronic Materials, The University of Wollongong, NSW 2500, Australia
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  • Gao Qing (Max) Lu

    Corresponding author
    1. ARC Centre of Excellence for Functional Nanomaterials, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, QLD 4072, Australia
    • ARC Centre of Excellence for Functional Nanomaterials, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, QLD 4072, Australia.
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Abstract

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Reducing ferromagnetic particle size is an important strategy to improve their positive effect on imaging through the suppression of their negative effect, demonstrated by ultrasmall manganese ferrite nanoparticles prepared from an environmentally-friendly aqueous route. These ultrasmall particles exhibit pronounced paramagnetic characteristics and nontoxicity, making them efficient T1-positive contrast agent and manganese contrast agents for manganese enhanced MRI.

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