Communication

Core–Shell Hydrogel Microcapsules for Improved Islets Encapsulation

  1. Minglin Ma1,4,
  2. Alan Chiu1,4,
  3. Gaurav Sahay1,
  4. Joshua C. Doloff1,4,
  5. Nimit Dholakia1,4,
  6. Raj Thakrar1,4,
  7. Joshua Cohen5,
  8. Arturo Vegas1,4,
  9. Delai Chen1,4,
  10. Kaitlin M. Bratlie6,
  11. Tram Dang1,4,
  12. Roger L. York1,4,
  13. Jennifer Hollister-Lock5,
  14. Gordon C. Weir5,
  15. Daniel G. Anderson1,2,3,4,5,*

Article first published online: 3 DEC 2012

DOI: 10.1002/adhm.201200341

Issue

Advanced Healthcare Materials

Advanced Healthcare Materials

Volume 2, Issue 5, pages 667–672, May, 2013

Additional Information

How to Cite

Ma, M., Chiu, A., Sahay, G., Doloff, J. C., Dholakia, N., Thakrar, R., Cohen, J., Vegas, A., Chen, D., Bratlie, K. M., Dang, T., York, R. L., Hollister-Lock, J., Weir, G. C. and Anderson, D. G. (2013), Core–Shell Hydrogel Microcapsules for Improved Islets Encapsulation. Advanced Healthcare Materials, 2: 667–672. doi: 10.1002/adhm.201200341

Author Information

  1. 1

    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA

  2. 2

    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA

  3. 3

    Division of Health Science Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA

  4. 4

    Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA

  5. 5

    Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA

  6. 6

    Departments of Materials Science & Engineering and Chemical & Biological Engineering, Iowa State University, Ames, IA, 50011

*David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.

Publication History

  1. Issue published online: 2 MAY 2013
  2. Article first published online: 3 DEC 2012
  3. Manuscript Received: 25 SEP 2012

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Keywords:

  • Islets encapsulation;
  • transplantation;
  • core-shell structures;
  • immuno-protection;
  • microcapsules;
  • hydrogels
Thumbnail image of graphical abstract

Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core–shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.

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