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Keywords:

  • Islets encapsulation;
  • transplantation;
  • core-shell structures;
  • immuno-protection;
  • microcapsules;
  • hydrogels
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Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core–shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.