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Core–Shell Hydrogel Microcapsules for Improved Islets Encapsulation

Authors

  • Minglin Ma,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
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  • Alan Chiu,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
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  • Gaurav Sahay,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
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  • Joshua C. Doloff,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
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  • Nimit Dholakia,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
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  • Raj Thakrar,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
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  • Joshua Cohen,

    1. Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
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  • Arturo Vegas,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
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  • Delai Chen,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
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  • Kaitlin M. Bratlie,

    1. Departments of Materials Science & Engineering and Chemical & Biological Engineering, Iowa State University, Ames, IA, 50011
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  • Tram Dang,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
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  • Roger L. York,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
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  • Jennifer Hollister-Lock,

    1. Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
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  • Gordon C. Weir,

    1. Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
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  • Daniel G. Anderson

    Corresponding author
    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    3. Division of Health Science Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    4. Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    5. Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    • David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
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Abstract

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Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core–shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.

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