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Fully Biodegradable Airway Stents Using Amino Alcohol-Based Poly(ester amide) Elastomers

Authors

  • Jane Wang,

    1. Charles Stark Draper Laboratory, Biomedical Engineering Center, Mail Stop 32, 555 Technology Square, Cambridge, MA 02139, USA
    2. Massachusetts Institute of Technology, 77 Massachusetts Ave, The David H. Koch Institute, Room 76-661, Cambridge, MA 02139-4307, USA
    Current affiliation:
    1. Department of Chemical Engineering at National Tsing-Hua University, Hsinchu, Taiwan, Republic of China.
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  • Kyle G. Boutin,

    1. Charles Stark Draper Laboratory, Biomedical Engineering Center, Mail Stop 32, 555 Technology Square, Cambridge, MA 02139, USA
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  • Omar Abdulhadi,

    1. University of South Carolina, 300 Main Street, Rm A219, Columbia, SC 2920
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  • Lyndia D. Personnat,

    1. Charles Stark Draper Laboratory, Biomedical Engineering Center, Mail Stop 32, 555 Technology Square, Cambridge, MA 02139, USA
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  • Tarek Shazly,

    1. University of South Carolina, 300 Main Street, Rm A219, Columbia, SC 2920
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  • Robert Langer,

    1. Massachusetts Institute of Technology, 77 Massachusetts Ave, The David H. Koch Institute, Room 76-661, Cambridge, MA 02139-4307, USA
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  • Colleen L. Channick,

    1. M.D, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA
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  • Jeffrey T. Borenstein

    Corresponding author
    1. Charles Stark Draper Laboratory, Biomedical Engineering Center, Mail Stop 32, 555 Technology Square, Cambridge, MA 02139, USA
    • Charles Stark Draper Laboratory, Biomedical Engineering Center, Mail Stop 32, 555 Technology Square, Cambridge, MA 02139, USA.
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Abstract

Airway stents are often used to maintain patency of the tracheal and bronchial passages in patients suffering from central airway obstruction caused by malignant tumors, scarring, and injury. Like most conventional medical implants, they are designed to perform their functions for a limited period of time, after which surgical removal is often required. Two primary types of airway stents are in general use, metal mesh devices and elastomeric tubes; both are constructed using permanent materials, and must be removed when no longer needed, leading to potential complications. This paper describes the development of process technologies for bioresorbable prototype elastomeric airway stents that would dissolve completely after a predetermined period of time or by an enzymatic triggering mechanism. These airway stents are constructed from biodegradable elastomers with high mechanical strength, flexibility and optical transparency. This work combines microfabrication technology with bioresorbable polymers, with the ultimate goal of a fully biodegradable airway stent ultimately capable of improving patient safety and treatment outcomes.

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