Combination Delivery of Antigens and CpG by Lanthanides-Based Core-Shell Nanoparticles for Enhanced Immune Response and Dual-Mode Imaging

Authors

  • Zhenhua Li,

    1. Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
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  • Zhen Liu,

    1. Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
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  • Meili Yin,

    1. Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
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  • Xinjian Yang,

    1. Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
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  • Jinsong Ren,

    Corresponding author
    1. Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
    • Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625.
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  • Xiaogang Qu

    Corresponding author
    1. Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
    • Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625.
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Abstract

original image

Europium-doped GdPO4 hollow spheres/polymer core-shell nanoparticles are functionalized with ovalbumin (OVA) as a model antigen and an oligonucleotide (CpG) that stimulates the immune response. These functionalized core-shell nanoparticles are used as vaccines, where they enable efficient delivery of an antigen to target sites, tracking of the vaccines using non-invasive clinical imaging technology.

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