Large-Scale Fabrication of Free-Standing, Micropatterned Silica Nanotubes Via a Hybrid Hydrogel-Templated Route

Authors

  • Song Chen,

    Corresponding author
    1. JSPS Research Fellow, 8 Ichibancho, Chiyoda-ku, Tokyo 102-8472, Japan
    2. Biomaterials Unit, National Institute for Materials Science, Sengen, Tsukuba 305–0047, Japan
    • Song Chen, JSPS Research Fellow, 8 Ichibancho, Chiyoda-ku, Tokyo 102-8472, Japan

      Nobutaka Hanagata, Biomaterials Unit, National Institute for Materials Science, Sengen, Tsukuba 305–0047, Japan.

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  • Xuetao Shi,

    1. WPI Advanced Institute for Materials Research, Tohoku University, Katahira 2-1-1, Aobaku, Sendai 980–8577, Japan
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  • Shanmugavel Chinnathambi,

    1. Biomaterials Unit, National Institute for Materials Science, Sengen, Tsukuba 305–0047, Japan
    2. Department of Medical Physics, Anna University, Chennai 600-025, India
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  • Nobutaka Hanagata

    Corresponding author
    1. Biomaterials Unit, National Institute for Materials Science, Sengen, Tsukuba 305–0047, Japan
    2. Graduate School of Life Science, Hokkaido University, N10W8, Kita-ku, Sapporo 060-0812, Japan
    • Song Chen, JSPS Research Fellow, 8 Ichibancho, Chiyoda-ku, Tokyo 102-8472, Japan

      Nobutaka Hanagata, Biomaterials Unit, National Institute for Materials Science, Sengen, Tsukuba 305–0047, Japan.

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Abstract

original image

Free-standing, micropatterned silica nanotube membranes are in situ fabricated using a micropatterned silica-coated collagen hybrid hydrogel as template. They are substrate-free, and not only maintained their micropatterned microstructure well, but also exhibited strong cell contact guidance ability to direct cell alignment and differentiation, indicating their good potential for biomedical applications.

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