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Human Erythrocytes Covered with Magnetic Core–Shell Nanoparticles for Multimodal Imaging

Authors

  • Mathieu Laurencin,

    1. Université Pierre et Marie Curie UPMC-CNRS, Laboratoire Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques PECSA UMR 7195, 4 place Jussieu, 75252 Paris, France
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  • Nithavong Cam,

    1. Université Pierre et Marie Curie UPMC-CNRS, Laboratoire Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques PECSA UMR 7195, 4 place Jussieu, 75252 Paris, France
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  • Thomas Georgelin,

    1. Université Pierre et Marie Curie UPMC-CNRS, Laboratoire Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques PECSA UMR 7195, 4 place Jussieu, 75252 Paris, France
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  • Olivier Clément,

    1. Plateforme d'Imagerie du Petit Animal Paris Descartes, Inserm UMR 970, Paris, Centre de Recherche Cardiovasculaire, 56 rue Leblanc, 75737 Paris Cedex 15
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  • Gwennhael Autret,

    1. Plateforme d'Imagerie du Petit Animal Paris Descartes, Inserm UMR 970, Paris, Centre de Recherche Cardiovasculaire, 56 rue Leblanc, 75737 Paris Cedex 15
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  • Jean-Michel Siaugue,

    1. Université Pierre et Marie Curie UPMC-CNRS, Laboratoire Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques PECSA UMR 7195, 4 place Jussieu, 75252 Paris, France
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  • Christine Ménager

    Corresponding author
    1. Université Pierre et Marie Curie UPMC-CNRS, Laboratoire Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques PECSA UMR 7195, 4 place Jussieu, 75252 Paris, France
    • Université Pierre et Marie Curie UPMC-CNRS, Laboratoire Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques PECSA UMR 7195, 4 place Jussieu, 75252 Paris, France.
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Abstract

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Surface functionalization of human red blood cells (hRBCs) with fluorescent and magnetic silica core-shell nanoparticles is used to design a carrier suitable for multimodal imaging with a long circulating time. The coated magnetic hRBCs show no hemolytic activity, while the advantage of the affinity of proteins for silica allows a further coating.

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