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Cu2–xSe Nanocrystals with Localized Surface Plasmon Resonance as Sensitive Contrast Agents for In Vivo Photoacoustic Imaging: Demonstration of Sentinel Lymph Node Mapping

Authors

  • Xin Liu,

    1. Department of Chemical and Biological Engineering, University at Buffalo (SUNY), Buffalo, NY 14260 USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Wing-Cheung Law,

    1. Institute for Lasers, Photonics, and Biophotonics, University at Buffalo (SUNY), Buffalo, NY 14260 USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Mansik Jeon,

    1. Department of Biomedical Engineering, University at Buffalo (SUNY), Buffalo, NY 14260 USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Xianliang Wang,

    1. Department of Chemical and Biological Engineering, University at Buffalo (SUNY), Buffalo, NY 14260 USA
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  • Maixian Liu,

    1. Institute for Lasers, Photonics, and Biophotonics, University at Buffalo (SUNY), Buffalo, NY 14260 USA
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  • Chulhong Kim,

    Corresponding author
    1. Department of Biomedical Engineering, University at Buffalo (SUNY), Buffalo, NY 14260 USA
    • Department of Biomedical Engineering, University at Buffalo (SUNY), Buffalo, NY 14260 USA.
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  • Paras N. Prasad,

    Corresponding author
    1. Institute for Lasers, Photonics, and Biophotonics, University at Buffalo (SUNY), Buffalo, NY 14260 USA
    • Institute for Lasers, Photonics, and Biophotonics, University at Buffalo (SUNY), Buffalo, NY 14260 USA
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  • Mark T. Swihart

    Corresponding author
    1. Department of Chemical and Biological Engineering, University at Buffalo (SUNY), Buffalo, NY 14260 USA
    • Department of Chemical and Biological Engineering, University at Buffalo (SUNY), Buffalo, NY 14260 USA
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Abstract

original image

The promise of a new nanomaterial, Cu2–xSe nanocrystals, as a contrast agent for photoacoustic imaging is demonstrated. The Cu2–xSe nanocrystals exhibit strong optical absorption at near infrared wavelengths that can efficiently penetrate tissue. In vivo photoacoustic tomography using this nanomaterial as the contrast agent provides clear three-dimensional resolution of a sentinel lymph node in a rat model.

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