A Self-Adjuvanting Supramolecular Vaccine Carrying a Folded Protein Antigen

Authors

  • Gregory A. Hudalla,

    1. Department of Surgery, University of Chicago, 5841 S. Maryland Ave. MC 5032, Chicago, IL 60637 USA
    2. Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Tech M292, Evanston, IL 60208-3109 USA
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  • Justin A. Modica,

    1. Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Tech M292, Evanston, IL 60208-3109 USA
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  • Ye F. Tian,

    1. Department of Surgery, University of Chicago, 5841 S. Maryland Ave. MC 5032, Chicago, IL 60637 USA
    2. Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL 60647
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  • Jai S. Rudra,

    1. Department of Surgery, University of Chicago, 5841 S. Maryland Ave. MC 5032, Chicago, IL 60637 USA
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  • Anita S. Chong,

    1. Department of Surgery, University of Chicago, 5841 S. Maryland Ave. MC 5032, Chicago, IL 60637 USA
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  • Tao Sun,

    1. Department of Surgery, University of Chicago, 5841 S. Maryland Ave. MC 5032, Chicago, IL 60637 USA
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  • Milan Mrksich,

    1. Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Tech M292, Evanston, IL 60208-3109 USA
    2. Department of Chemistry, Northwestern University, 2145 Sheridan Road, Tech M292, Evanston, IL 60208-3109 USA
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  • Joel H. Collier

    Corresponding author
    1. Department of Surgery, University of Chicago, 5841 S. Maryland Ave. MC 5032, Chicago, IL 60637 USA
    2. Committee on Molecular Medicine, University of Chicago, 5841 S. Maryland Ave. MC 5032, Chicago, IL 60637 USA
    • Department of Surgery, University of Chicago, 5841 S. Maryland Ave. MC 5032, Chicago, IL 60637 USA.

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Abstract

original image

This work illustrates a strategy for the design of molecularly defined immunotherapies, using a blend of supramolecular peptide self-assembly and active site-directed protein capture.

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