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Nanoceria-Triggered Synergetic Drug Release Based on CeO2-Capped Mesoporous Silica Host–Guest Interactions and Switchable Enzymatic Activity and Cellular Effects of CeO2

Authors

  • Can Xu,

    1. Division of Biological Inorganic Chemistry, State Key laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: (+ 86) 431-85262656
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  • Youhui Lin,

    1. Division of Biological Inorganic Chemistry, State Key laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: (+ 86) 431-85262656
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  • Jiasi Wang,

    1. Division of Biological Inorganic Chemistry, State Key laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: (+ 86) 431-85262656
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  • Li Wu,

    1. Division of Biological Inorganic Chemistry, State Key laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: (+ 86) 431-85262656
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  • Weili Wei,

    1. Division of Biological Inorganic Chemistry, State Key laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: (+ 86) 431-85262656
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  • Jinsong Ren,

    1. Division of Biological Inorganic Chemistry, State Key laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: (+ 86) 431-85262656
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  • Xiaogang Qu

    Corresponding author
    1. Division of Biological Inorganic Chemistry, State Key laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: (+ 86) 431-85262656
    • Division of Biological Inorganic Chemistry, State Key laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: (+ 86) 431-85262656.

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Abstract

Herein, a pH stimuli-responsive vehicle for intracellular drug delivery using CeO2 capped mesoporous silica nanoparticles (MSN) is reported. β-Cyclodextrin-modified CeO2 nanoparticles could cap onto ferrocene-functionalized mesoporous silica through host–guest interactions. After internalization into A549 cells by a lysosomal pathway, the ferrocenyl moieties are oxidized to ferrocenium ions by CeO2 lids, which could trigger the uncapping of the CeO2 and cause the drugs release. Because of the pH-dependent toxicity, the CeO2 here behaves as a multi-purpose entity that not only acts as a lid but also exhibits a synergistic antitumor effect on cancer cells. Meanwhile, the cell protective effect of CeO2 nanoparticles alone is demonstrated, which ensures that the dissolved CeO2 nanoparticles can be non-toxic to normal cells.

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