Functional Living Biointerphases

Authors

  • Anas Saadeddin,

    1. Abengoa Research, Abengoa, Campus Palmas Altas, Sevilla, Spain
    Current affiliation:
    1. These authors contributed equally to this work
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  • Aleixandre Rodrigo-Navarro,

    1. Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Valencia, Spain
    Current affiliation:
    1. These authors contributed equally to this work
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  • Vicente Monedero,

    1. Laboratorio de Bacterias Lácticas y Probióticos, Instituto de Agroquímica y Tecnología de Alimentos-CSIC, Paterna, Valencia, Spain
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  • Patricia Rico,

    1. Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Valencia, Spain
    2. CIBER de Bioingeniería, Biomateriales y Nanomedicina, Spain
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  • David Moratal,

    1. Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Valencia, Spain
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  • María Luisa González-Martín,

    1. CIBER de Bioingeniería, Biomateriales y Nanomedicina, Spain
    2. Departamento de Física Aplicada, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain
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  • David Navarro,

    1. Servicio de Microbiología. Hospital Clínico Universitario, Valencia, Spain
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  • Andrés J. García,

    1. Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
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  • Manuel Salmerón-Sánchez

    Corresponding author
    1. Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Valencia, Spain
    2. CIBER de Bioingeniería, Biomateriales y Nanomedicina, Spain
    • Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Valencia, Spain.
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Abstract

original image

Lactococcus lactis is modified to express a fibronectin fragment (FNIII7-10) as a membrane protein. This interphase, based on a living system, can be further exploited to provide spatio-temporal factors to direct cell function at the material interface. This approach establishes a new paradigm in biomaterial surface functionalization for biomedical applications.

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