Controlled Drug Release: Mesoporous Silica Nanoparticle-based H2O2 Responsive Controlled-Release System Used for Alzheimer's Disease Treatment (Adv. Healthcare Mater. 3/2012)

Authors

  • Jie Geng,

    1. Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: +86-431-85262656
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  • Meng Li,

    1. Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: +86-431-85262656
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  • Li Wu,

    1. Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: +86-431-85262656
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  • Cuie Chen,

    1. Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: +86-431-85262656
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  • Xiaogang Qu

    Corresponding author
    1. Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: +86-431-85262656
    • Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: +86-431-85262656.
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Abstract

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On page 332, Xiaogang Qu and co-workers present a novel strategy for Alzheimer's disease treatment using a H2O2-responsive controlled-release system based on mesoporous silica nanoparticles. By taking advantage of the good biocompatibility, cellular uptake properties, and efficient intracellular release of metal chelators, the delivery system is promising for future in vivo biomedical applications.

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