Photo-induced Drug Delivery: Cascaded Photoinduced Drug Delivery to Cells from Multifunctional Core–Shell Mesoporous Silica (Adv. Healthcare Mater. 3/2012)

Authors

  • Axel Schloßbauer,

    1. Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany
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  • Anna M. Sauer,

    1. Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany
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  • Valentina Cauda,

    1. Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany
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  • Alexandra Schmidt,

    1. Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany
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  • Hanna Engelke,

    1. Department of Physics and Center for Nanoscience, University of Munich (LMU), Geschwister-Scholl-Platz 1, 80539 Munich, Germany
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  • Ulrich Rothbauer,

    1. BioCenter and Center for NanoScience (CeNS), University of Munich (LMU), Grosshadernerstr. 2, 82152 Planegg-Martinsried, Germany
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  • Kourosh Zolghadr,

    1. BioCenter and Center for NanoScience (CeNS), University of Munich (LMU), Grosshadernerstr. 2, 82152 Planegg-Martinsried, Germany
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  • Heinrich Leonhardt,

    1. BioCenter and Center for NanoScience (CeNS), University of Munich (LMU), Grosshadernerstr. 2, 82152 Planegg-Martinsried, Germany
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  • Christoph Bräuchle,

    Corresponding author
    1. Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany
    • Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany.
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  • Thomas Bein

    Corresponding author
    1. Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany
    • Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany.
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Abstract

original image

On page 316, Thomas Bein, Christoph Bräuchle, and co-workers present a drug delivery platform based on colloidal mesoporous silica. In order to provide light-triggered, intracellular drug release, photosensitizers are attached to the particles surface. The light-generated singlet oxygen is used to destroy a supported lipid bilayer and the endosomal membrane in a cascaded manner, leading to the release of bioactive species into the cytosol. Confocal fluorescence microscopy is used to characterize the release processes.

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