SEARCH

SEARCH BY CITATION

Keywords:

  • virus;
  • biomineralization;
  • shell engineering;
  • neutralization escape;
  • tropism expansion
Thumbnail image of graphical abstract

Viruses in nanoscale are ideal templates for functional modification by chemical or material methods. On page 443, Chengfeng Qin, Ruikang Tang, Xiaoyu Wang, and co-workers present a novel surface modification strategy to afford a biocompatible and bio-degradable calcium phosphate (CaPi) shell onto single virus. Biomineralization-based virus shell engineering generates a Trojan virus that can enter cells in a receptor-independent manner and escape neutralization by antibodies, opening up multiple applications in biomedicines and materials.