Drug Delivery: Surface-Adhered Composite Poly(Vinyl Alcohol) Physical Hydrogels: Polymersome-Aided Delivery of Therapeutic Small Molecules (Adv. Healthcare Mater. 6/2012)



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The assembly of a composite hydrogel for substrate-mediated drug delivery is reported by B. Städler and co-workers on page 791. Poly(N-acryloyl morpholine)-block-poly(cholesteryl acrylate)-block-poly(N-acryloyl morpholine) is synthesized and its self-assembly into polymersomes is shown. Polymersomeaided trapping of a cytotoxic hydrophobic compound in a poly(dopamine)-coated poly(vinyl alcohol) hydrogel matrix leads to reduction in viability of adhering cells.