• axonal growth;
  • conducting polymer;
  • hydrogel;
  • poly(3,4-ethylenedioxythiophene);
  • tissue engineering
Thumbnail image of graphical abstract

Conduit hydrogels have been considered for axonal regeneration in both central and peripheral nervous systems. However, a drawback of hydrogel conduits is their lack of mechanical integrity and strength under physiological conditions. On page 762, M. R. Abidian and co-workers report a novel method for preparation of mechanically reinforced agarose nerve conduits that are then made conductive by use of a thin layer of conducting polymer pol(3,4-ethylenedioxythiophene) (PEDOT). The front cover illustrates axon guidance and growth inside a partially coated PEDOT agarose hydrogel conduit.