Gold Nanoparticle-Loaded Neural Stem Cells for Photothermal Ablation of Cancer

Authors

  • Kenna Schnarr,

    1. Department of Neurosciences, Beckman Research Institute, Irell & Manella Graduate School of Biological Sciences, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010 United States
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  • Rachael Mooney,

    1. Department of Neurosciences, Beckman Research Institute, Irell & Manella Graduate School of Biological Sciences, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010 United States
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  • Yiming Weng,

    1. Department of Molecular Medicine, Beckman Research Institute, Irell & Manella Graduate School of Biological Sciences, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010 United States
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  • Donghong Zhao,

    1. Department of Neurosciences, Beckman Research Institute, Irell & Manella Graduate School of Biological Sciences, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010 United States
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  • Elizabeth Garcia,

    1. Department of Neurosciences, Beckman Research Institute, Irell & Manella Graduate School of Biological Sciences, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010 United States
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  • Brian Armstrong,

    1. Department of Neurosciences, Beckman Research Institute, Irell & Manella Graduate School of Biological Sciences, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010 United States
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  • Alexander J. Annala,

    1. Department of Neurosciences, Beckman Research Institute, Irell & Manella Graduate School of Biological Sciences, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010 United States
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  • Seung U. Kim,

    1. Department of Medicine, Division of Neurology, UBC Hospital, University of British Columbia, Vancouver, British Columbia V6T2B5 Canada
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  • Karen S. Aboody,

    Corresponding author
    1. Department of Neurosciences, Division of Neurosurgery, Beckman Research Institute, Irell & Manella Graduate School of Biological Sciences, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010 United States
    • Department of Neurosciences, Division of Neurosurgery, Beckman Research Institute, Irell & Manella Graduate School of Biological Sciences, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010 United States.
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  • Jacob M. Berlin

    Corresponding author
    1. Department of Molecular Medicine, Beckman Research Institute, Irell & Manella Graduate School of Biological Sciences, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010 United States
    • Department of Molecular Medicine, Beckman Research Institute, Irell & Manella Graduate School of Biological Sciences, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010 United States
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Abstract

original image

Neural stem cells maintain their tumor tropism after internalizing gold nanorods. When exposed to a laser, the loaded cells heat up, destroying surrounding tumor cells.

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