pH-Controlled Delivery of Nanoparticles into Tumor Cells

Authors

  • Liang Han,

    1. Key Laboratory of Smart Drug Delivery, Ministry of Education& PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
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  • Haojun Ma,

    1. Key Laboratory of Smart Drug Delivery, Ministry of Education& PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
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  • Yubo Guo,

    1. Key Laboratory of Smart Drug Delivery, Ministry of Education& PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
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  • Yuyang Kuang,

    1. Key Laboratory of Smart Drug Delivery, Ministry of Education& PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
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  • Xi He,

    1. Key Laboratory of Smart Drug Delivery, Ministry of Education& PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
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  • Chen Jiang

    Corresponding author
    1. Key Laboratory of Smart Drug Delivery, Ministry of Education& PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
    • Key Laboratory of Smart Drug Delivery, Ministry of Education& PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.

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Abstract

original image

Nanoparticles target tumor cells by pH-controlled means. Nanoparticles carry three synergistic delivery functions: 1) tumor tissue targeting by the EPR effect; 2) tumor cell targeting by pHLIP-mediated membrane-localization; and 3) tumor cell uptake by adsorptive-mediated endocytosis.

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