Nano-Graphene Oxide: A Potential Multifunctional Platform for Cancer Therapy

Authors

  • Gil Gonçalves,

    Corresponding author
    1. TEMA-NRD, Mechanical Engineering Department and Aveiro Institute of Nanotechnology (AIN), University of Aveiro, 3810-193 Aveiro, Portugal
    • Gil Gonçalves, TEMA-NRD, Mechanical Engineering Department and Aveiro Institute of Nanotechnology (AIN), University of Aveiro, 3810-193 Aveiro, Portugal

      Mercedes Vila, Department of Inorganic and Bioinorganic Chemistry, Faculty of Pharmacy, Universidad Complutense de Madrid, 28040 Madrid, Spain.

      Paula Alexandrina A. P. Marques, TEMA-NRD, Mechanical Engineering Department and Aveiro Institute of Nanotechnology (AIN), University of Aveiro, 3810-193 Aveiro, Portugal

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  • Mercedes Vila,

    Corresponding author
    1. Department of Inorganic and Bioinorganic Chemistry, Faculty of Pharmacy, Universidad Complutense de Madrid, 28040 Madrid, Spain
    2. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Spain
    • Gil Gonçalves, TEMA-NRD, Mechanical Engineering Department and Aveiro Institute of Nanotechnology (AIN), University of Aveiro, 3810-193 Aveiro, Portugal

      Mercedes Vila, Department of Inorganic and Bioinorganic Chemistry, Faculty of Pharmacy, Universidad Complutense de Madrid, 28040 Madrid, Spain.

      Paula Alexandrina A. P. Marques, TEMA-NRD, Mechanical Engineering Department and Aveiro Institute of Nanotechnology (AIN), University of Aveiro, 3810-193 Aveiro, Portugal

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  • María-Teresa Portolés,

    1. Department of Biochemistry and Molecular Biology I, Faculty of Chemistry, Universidad Complutense de Madrid, 28040 Madrid, Spain
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  • María Vallet-Regi,

    1. Department of Inorganic and Bioinorganic Chemistry, Faculty of Pharmacy, Universidad Complutense de Madrid, 28040 Madrid, Spain
    2. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Spain
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  • José Gracio,

    1. TEMA-NRD, Mechanical Engineering Department and Aveiro Institute of Nanotechnology (AIN), University of Aveiro, 3810-193 Aveiro, Portugal
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  • Paula Alexandrina A. P. Marques

    Corresponding author
    1. TEMA-NRD, Mechanical Engineering Department and Aveiro Institute of Nanotechnology (AIN), University of Aveiro, 3810-193 Aveiro, Portugal
    • Gil Gonçalves, TEMA-NRD, Mechanical Engineering Department and Aveiro Institute of Nanotechnology (AIN), University of Aveiro, 3810-193 Aveiro, Portugal

      Mercedes Vila, Department of Inorganic and Bioinorganic Chemistry, Faculty of Pharmacy, Universidad Complutense de Madrid, 28040 Madrid, Spain.

      Paula Alexandrina A. P. Marques, TEMA-NRD, Mechanical Engineering Department and Aveiro Institute of Nanotechnology (AIN), University of Aveiro, 3810-193 Aveiro, Portugal

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Errata

This article is corrected by:

  1. Errata: Nano-Graphene Oxide: A Potential Multifunctional Platform for Cancer Therapy Volume 3, Issue 7, 956, Article first published online: 10 July 2014

Abstract

Nano-GO is a graphene derivative with a 2D atomic layer of sp2 bonded carbon atoms in hexagonal conformation together with sp3 domains with carbon atoms linked to oxygen functional groups. The supremacy of nano-GO resides essentially in its own intrinsic chemical and physical structure, which confers an extraordinary chemical versatility, high aspect ratio and unusual physical properties. The chemical versatility of nano-GO arises from the oxygen functional groups on the carbon structure that make possible its relatively easy functionalization, under mild conditions, with organic molecules or biological structures in covalent or non-covalent linkage. The synergistic effects resulting from the assembly of well-defined structures at nano-GO surface, in addition to its intrinsic optical, mechanical and electronic properties, allow the development of new multifunctional hybrid materials with a high potential in multimodal cancer therapy. Herein, a comprehensive review of the fundamental properties of nano-GO requirements for cancer therapy and the first developments of nano-GO as a platform for this purpose is presented.

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