Antibody-Functionalized Magnetic Polymersomes: In vivo Targeting and Imaging of Bone Metastases using High Resolution MRI

Authors

  • Line Pourtau,

    1. Centre de Résonance Magnétique, des Systèmes Biologiques, UMR 5536, Université Bordeaux Segalen, CNRS, France
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Hugo Oliveira,

    1. Université de Bordeaux, LCPO, UMR 5629, F-33600 Pessac, France, CNRS, LCPO, UMR 5629, F-33600 Pessac, France
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Julie Thevenot,

    1. Université de Bordeaux, LCPO, UMR 5629, F-33600 Pessac, France, CNRS, LCPO, UMR 5629, F-33600 Pessac, France
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  • Yali Wan,

    1. Université de Bordeaux, CNRS, Chimie et Biologie des Membranes et des Nanoobjets (UMR5248), 33600 Pessac, France
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  • Alain R. Brisson,

    1. Université de Bordeaux, CNRS, Chimie et Biologie des Membranes et des Nanoobjets (UMR5248), 33600 Pessac, France
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  • Olivier Sandre,

    1. Université de Bordeaux, LCPO, UMR 5629, F-33600 Pessac, France, CNRS, LCPO, UMR 5629, F-33600 Pessac, France
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  • Sylvain Miraux,

    1. Centre de Résonance Magnétique, des Systèmes Biologiques, UMR 5536, Université Bordeaux Segalen, CNRS, France
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  • Eric Thiaudiere,

    Corresponding author
    1. Centre de Résonance Magnétique, des Systèmes Biologiques, UMR 5536, Université Bordeaux Segalen, CNRS, France
    • Eric Thiaudiere, Centre de Résonance Magnétique, des Systèmes Biologiques, UMR 5536, Université Bordeaux Segalen, CNRS, France

      Sébastien Lecommandoux, Université de Bordeaux, LCPO, UMR 5629, F-33600 Pessac, France, CNRS, LCPO, UMR 5629, F-33600 Pessac, France.

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  • Sébastien Lecommandoux

    Corresponding author
    1. Université de Bordeaux, LCPO, UMR 5629, F-33600 Pessac, France, CNRS, LCPO, UMR 5629, F-33600 Pessac, France
    • Eric Thiaudiere, Centre de Résonance Magnétique, des Systèmes Biologiques, UMR 5536, Université Bordeaux Segalen, CNRS, France

      Sébastien Lecommandoux, Université de Bordeaux, LCPO, UMR 5629, F-33600 Pessac, France, CNRS, LCPO, UMR 5629, F-33600 Pessac, France.

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Abstract

original image

Multifunctional polymersomes loaded with maghemite nanoparticles and grafted with an antibody, directed against human endothelial receptor 2, are developed as novel MRI contrast agents for bone metastasis imaging. Upon administration in mice bearing bone tumor grown from human breast cancer cells, MR images show targeting and enhanced retention of antibody-labeled polymersomes at the tumor site.

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