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Keywords:

  • skeletal tissue engineering;
  • mussel adhesion;
  • polydopamine;
  • nanofiber alignment;
  • myogenic differentiation
Thumbnail image of graphical abstract

The combined effect of mussel-inspired polydopamine (PDA) surface functionalization and topographical cues on the behavior of skeletal myoblasts is described. On PDA-modified nanofibers, myogenic protein expression and the fusion of myoblasts are increased significantly compared with those on unmodified nanofibers. The multinucleate myotubes on the aligned nanofibers are oriented in a direction parallel to the nanofibers.