Fluorescence Imaging Enabled Biodegradable Photostable Polymeric Micelles

Authors

  • Dipendra Gyawali,

    1. Department of Bioengineering The University of Texas at Arlington Arlington, TX 76010, USA
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  • Shengyuan Zhou,

    1. Department of Bioengineering The University of Texas at Arlington Arlington, TX 76010, USA
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  • Richard T. Tran,

    1. Department of Bioengineering Materials Research Institute Huck Institutes of The Life Sciences The Pennsylvania State University University Park, PA 16802, USA
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  • Yi Zhang,

    1. Department of Bioengineering The University of Texas at Arlington Arlington, TX 76010, USA
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  • Chao Liu,

    1. Department of Bioengineering Materials Research Institute Huck Institutes of The Life Sciences The Pennsylvania State University University Park, PA 16802, USA
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  • Xiaochun Bai,

    1. Academy of Orthopedics Guangdong Province The Third Affiliated Hospital Southern Medical University Guangzhou 510280, China
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  • Jian Yang

    Corresponding author
    1. Department of Bioengineering Materials Research Institute Huck Institutes of The Life Sciences The Pennsylvania State University University Park, PA 16802, USA
    • Department of Bioengineering Materials Research Institute Huck Institutes of The Life Sciences The Pennsylvania State University University Park, PA 16802, USA.

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Abstract

original image

Amphiphilic biodegradable photoluminescent polymers (ABPLPs) composed of a biodegradable fluorescent polymer and methoxy poly (ethyleneglycol) demonstrate intrinsic bright, tunable, and stable fluorescence emission. ABPLP micelles elicit minor cellular toxicity and can be used for cell and tissue imaging both in vitro and in vivo.

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